BDBM605618 US11673893, Example 87

SMILES CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl

InChI Key InChIKey=CIVWJLUNRPRKCE-DOTOQJQBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605618   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605618(US11673893, Example 87)
Affinity DataIC50:  117nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605618(US11673893, Example 87)
Affinity DataIC50:  0.837nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM605618(US11673893, Example 87)
Affinity DataIC50:  65nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent