BDBM610457 N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 8

SMILES O=C(Nc1cnccc1-c1ccc(cc1)C#N)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=NDAFUJBJGDJBNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610457   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[...)
Affinity DataIC50:  1.10nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[...)
Affinity DataIC50:  160nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[...)
Affinity DataIC50:  0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent