BDBM614220 US11746110, Example 15

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4c(Nc5cnn(C)c5)ccnn34)cc2C(F)(F)F)CC1

InChI Key InChIKey=SXIDXVGGABQPIG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 614220   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM614220(US11746110, Example 15)
Affinity DataIC50:  3.24nMAssay Description:Reagents and materials: ABL (ThermoFisher, Cat. No. PV3585), ABL T315I(Thermo Fisher, Cat. No. PR7429B), Ret (Carna, Cat. No. 08-159-10 ug), RET...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM614220(US11746110, Example 15)
Affinity DataIC50:  1.42nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM614220(US11746110, Example 15)
Affinity DataIC50:  0.370nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
Shenzhen Targetrx

US Patent
LigandPNGBDBM614220(US11746110, Example 15)
Affinity DataIC50:  4.28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent