BDBM622276 4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (Compound 22) and 4-amino-N-(1-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide ::US20230312556, Compound 23

SMILES Cc1ccc2c(nccc2c1NC(=O)c1csc2c(N)ncnc12)C(O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=OQYICUCPIYMDHT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622276   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622276(4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...)
Affinity DataIC50:  51.4nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622276(4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...)
Affinity DataIC50:  3.93nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622276(4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...)
Affinity DataIC50:  13.2nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent