BDBM622276 4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (Compound 22) and 4-amino-N-(1-(hydroxy(3-(trifluoromethyl)phenyl)methyl)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide ::US20230312556, Compound 23
SMILES Cc1ccc2c(nccc2c1NC(=O)c1csc2c(N)ncnc12)C(O)c1cccc(c1)C(F)(F)F
InChI Key InChIKey=OQYICUCPIYMDHT-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 622276
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 51.4nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 3.93nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 13.2nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair