BDBM622285 4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-methylisoquinolin-5-yl)quinazoline-8-carboxamide ::US20230312556, Compound 60
SMILES COc1ccc(Nc2nccc3c(NC(=O)c4cccc5c(NCc6ccc(OC)cc6OC)ncnc45)c(C)ccc23)c(F)c1
InChI Key InChIKey=QRCGEZVLUUMFAF-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 622285
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 8.48nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 3.14nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Sichuan Kelun-Biotech Biopharmaceutical
US Patent
Affinity DataIC50: 6.31nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair