BDBM622421 US20230312576, Compound 77

SMILES COc1cccc(c1)-c1cccc(NC(=O)N2CCC(=CC2)c2ncnc3[nH]cc(C4CC4)c23)c1

InChI Key InChIKey=ZEVYGJZIWQEHME-UHFFFAOYSA-N

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 622421   

TargetLIM domain kinase 2(Homo sapiens (Human))
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM622421(US20230312576, Compound 77)
Affinity DataKi:  4.64nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLIM domain kinase 1(Homo sapiens (Human))
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM622421(US20230312576, Compound 77)
Affinity DataKi:  22.2nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent