BDBM622543 (7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 46

SMILES COc1c(F)cc(Cn2cc(CNc3nc(C)c4NC(=O)[C@H](C)N(C)c4n3)cn2)cc1F

InChI Key InChIKey=AOPGRPZXPVBPEK-LBPRGKRZSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622543   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM622543((7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyra...)
Affinity DataKi: >4.00E+3nMAssay Description:Compounds were screened for their ability to inhibit Plk1 using a radioactive-phosphate incorporation assay. Assays were carried out in a mixture of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent