BDBM622567 (7S)-4,7,8-trimethyl-2-((cis-3-((5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 275

SMILES C[C@@H]1N(C)c2nc(N[C@@H]3C[C@H](Cn4nccc4C(F)(F)F)C3)nc(C)c2NC1=O

InChI Key InChIKey=BUVHAXVKOBMPIT-SDDRHHMPSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622567   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM622567((7S)-4,7,8-trimethyl-2-((cis-3-((5-(trifluoromethy...)
Affinity DataKi: >4.00E+3nMAssay Description:Compounds were screened for their ability to inhibit Plk1 using a radioactive-phosphate incorporation assay. Assays were carried out in a mixture of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent