BDBM624479 (2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin- 4-yl)ethyl)(imino)(methyl)-lambda6-sulfanone::US11780849, Compound 8

SMILES COc1cc2ncnc(N3CCC(CCS(C)(=N)=O)CC3)c2cc1OC

InChI Key InChIKey=WMWWXOFVXMYZDM-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 624479   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Volastra Therapeutics

US Patent
LigandPNGBDBM624479((2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin- 4-y...)
Affinity DataKi: <3nMAssay Description:Assay 2: Compared to the conditions in Assay 1, this assay has a larger dynamic range and ensures the system is under steady-state conditions by redu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Volastra Therapeutics

US Patent
LigandPNGBDBM624479((2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin- 4-y...)
Affinity DataKi:  690nMAssay Description:Assay 2: Compared to the conditions in Assay 1, this assay has a larger dynamic range and ensures the system is under steady-state conditions by redu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Volastra Therapeutics

US Patent
LigandPNGBDBM624479((2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin- 4-y...)
Affinity DataIC50:  4.10E+3nMAssay Description:Assay 1: Test compounds were plated in a 3 dilution scheme in a 384 well plate. To 50 nL of test compound in DMSO was added 2.5 μL ENPP-1 ECD in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Volastra Therapeutics

US Patent
LigandPNGBDBM624479((2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin- 4-y...)
Affinity DataIC50: <10nMAssay Description:Assay 1: Test compounds were plated in a 3 dilution scheme in a 384 well plate. To 50 nL of test compound in DMSO was added 2.5 μL ENPP-1 ECD in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent