BDBM625243 N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)propanamide (Racemate)::US20230322767, Example 69::US20230322767, Example 70::US20230322767, Example 71

SMILES CC(C(=O)Nc1cc(ccn1)-c1[nH]c2CCN(C)C(=O)c2c1-c1ccc(F)cc1F)c1ccc(F)cc1

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 625243   

TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  3.10nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1A1, expressed by baculovirus infected insect cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetcsnk1d(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  2.80nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1D, expressed by baculovirus infected insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  16nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1A1, expressed by baculovirus infected insect cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetcsnk1d(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  7.60nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1D, expressed by baculovirus infected insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50: >2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetcsnk1d(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  2.10nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1D, expressed by baculovirus infected insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50: >2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50: >2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM625243(N-{4-[3-(2,4-difluorophenyl)-5-methyl-4-oxo-4,5,6,...)
Affinity DataIC50:  1.70nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and full-length human CSNK1A1, expressed by baculovirus infected insect cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent