BDBM625598 US20230322822, Compound 14
SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1
InChI Key InChIKey=XOMJKMJVRWIBPL-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 625598
TargetEpidermal growth factor receptor [1-18,20-1210](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 16.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 620nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 3.60nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 16.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 10.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Targetegfr-c797s/ t790m/del19(Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 6.60nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 65.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 12.9nMAssay Description:To assess the effect of compounds on the activity of EML4-ALK kinases, kinase activity was tested by measuring ATP consumption in an enzymatic reacti...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 2.30nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 43.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 17.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,C797S](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 31.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 76.4nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Targetegfr-c797s/ t790m/del19(Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 18.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Homo sapiens (Human))
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
US Patent
Affinity DataIC50: 5.70nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair