BDBM627513 N-(4-(4-amino-1-isopropyl-7-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-2,5-difluorophenyl)-2-chloro-5-ethoxybenzenesulfonamide::US20230331719, Compound A17

SMILES CCOc1ccc(Cl)c(c1)S(=O)(=O)Nc1cc(F)c(cc1F)-c1nn(C(C)C)c2c(cnc(N)c12)[C@H]1CC[C@@H](CC1)N1CCOCC1

InChI Key InChIKey=SYELSIWJXRYYNQ-MEMLXQNLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627513   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Optikira

US Patent
LigandPNGBDBM627513(N-(4-(4-amino-1-isopropyl-7-((1r,4r)-4-morpholinoc...)
Affinity DataIC50:  2.10nMAssay Description:The RNase reactions were performed in 384 well black ProxiPlate-384 Plus plates (PERKIN Elmer) using 50 mM Tris assay buffer with 0.5 mM MgCl2, 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Optikira

US Patent
LigandPNGBDBM627513(N-(4-(4-amino-1-isopropyl-7-((1r,4r)-4-morpholinoc...)
Affinity DataIC50:  4.80nMAssay Description:The kinase reactions were performed in 384 well white ProxiPlate-384 Plus plates (PERKIN Elmer 6008280) using 25 mM MOPS assay buffer with 1 mM dithi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent