BDBM6301 6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Pyrido-[2,3-d]-pyrimidin-7-one 35::pyrido[2,3-d]pyrimidin-7-one 29

SMILES Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc12

InChI Key InChIKey=NTQUCCVMCHSPRQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 6301   

LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  439nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  439nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  439nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  950nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  2.62E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed