BDBM632975 N-(2-chloro-4- (difluoromethyl)thiophen-3-yl)-2-((6- (3,4-dimethylpiperazin-1-yl)-2-methyl- pyrimidin-4-yl)amino)thiazole-5- carboxamide::US20230348453, Compound E13

SMILES CN1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(Cl)scc2C(F)F)nc(C)n1

InChI Key InChIKey=ZATJAIQPRBTMDO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 632975   

TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
Iomx Therapeutics

US Patent
LigandPNGBDBM632975(N-(2-chloro-4- (difluoromethyl)thiophen-3-yl)-2-((...)
Affinity DataIC50: <20nMAssay Description:The IC50 for the inhibition of ABL1 by dasatinib, by C7 and by B3 is approximately 1.5 nM, 5.1 nM and 1.6 nM, and of SRC is 1.5 nM, 1.5 nM and 1.5 nM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
Iomx Therapeutics

US Patent
LigandPNGBDBM632975(N-(2-chloro-4- (difluoromethyl)thiophen-3-yl)-2-((...)
Affinity DataIC50: <10nMAssay Description:The IC50 for the inhibition of ABL1 by dasatinib, by C7 and by B3 is approximately 1.5 nM, 5.1 nM and 1.6 nM, and of SRC is 1.5 nM, 1.5 nM and 1.5 nM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent