BDBM636722 (R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperidin-4-ylsulfonyl)-2-hydroxy-2-methylpropanamide ::US11826430, Compound 1.4

SMILES C[C@](O)(CS(=O)(=O)C1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636722   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636722((R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  0.600nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636722((R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  1.03E+3nMAssay Description:AR in LNCaP cytosol was used for determining the binding affinity of test articles and the reference compound progesterone (Sigma, Cat: E2785, St. Lo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM636722((R)—N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(1-(2-...)
Affinity DataIC50:  0.200nMAssay Description:i. PARP1 assay: Human recombinant PARP1 at a final concentration of 2.5 nM was combined with histone H4 (20 μM) and test articles at various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent