BDBM642760 1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1H-[1,2,3] triazolo[4,5-h]quinazolin-8-amine::US20230416271, Compound II.14::US20230416271, Compound II.25::US20230416271, Compound II.37

SMILES CC(C)n1nnc2ccc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc3c12

InChI Key InChIKey=MRPVMOCAEFVNTQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 642760   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  0.200nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  3nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  5nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  0.200nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  12nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  5nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  0.5nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  4nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Chengdu Cynogen Bio-Pharmaceutical Technology

US Patent
LigandPNGBDBM642760(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1...)
Affinity DataIC50:  3nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent