BDBM642987 US20240000767, Example 131::US20240000767, Example 132::US20240000767, Example 65::rac-2-[4-(1,1-Difluoro-5-azaspiro[2.5]octan-5-yl)piperidin-1-yl]-N-[(3,5-difluoropyridin-2-yl)methyl]-1,3-thiazole-5-carboxamide

SMILES Fc1cnc(CNC(=O)c2cnc(s2)N2CCC(CC2)N2CCCC3(CC3(F)F)C2)c(F)c1

InChI Key InChIKey=GEIIJNRSUPZTGW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 642987   

TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM642987(US20240000767, Example 131 | US20240000767, Exampl...)
Affinity DataIC50:  4.5nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM642987(US20240000767, Example 131 | US20240000767, Exampl...)
Affinity DataIC50:  0.710nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM642987(US20240000767, Example 131 | US20240000767, Exampl...)
Affinity DataIC50:  1.90nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent