BDBM64682 US9475819, 10A
SMILES Cc1ccc(c(c1)C(=O)N1[C@@H]2CC[C@H]1[C@H](COc1ccc(F)cn1)C2)-n1nccn1
InChI Key InChIKey=FNSBFXNNFNCHOW-WDYCEAGBSA-N
Data 5 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 64682
Affinity DataKi: 3nM ΔG°: -10.8kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -10.6kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Affinity DataKi: 32nM ΔG°: -10.7kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Binding affinity to human OX2RMore data for this Ligand-Target Pair