BDBM647315 N-((1H- benzo[d]imidazol-2- yl)methyl)-3-(4- cyanophenyl)imidazo [1,2-a]pyridine-7- carboxamide::US20240025892, Example 22

SMILES O=C(NCc1nc2ccccc2[nH]1)c1ccn2c(cnc2c1)-c1ccc(cc1)C#N

InChI Key InChIKey=UEOOSASFOHAWBP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647315   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647315(N-((1H- benzo[d]imidazol-2- yl)methyl)-3-(4- cyano...)
Affinity DataIC50:  5.58nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647315(N-((1H- benzo[d]imidazol-2- yl)methyl)-3-(4- cyano...)
Affinity DataIC50:  1.30E+4nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
The General Hospital

US Patent
LigandPNGBDBM647315(N-((1H- benzo[d]imidazol-2- yl)methyl)-3-(4- cyano...)
Affinity DataIC50:  497nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent