BDBM647340 4-(7-(1-ethyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyridin-3-yl)-2- methylbenzonitrile::US20240025892, Example 47

SMILES CCn1cc(cn1)-c1ccn2c(cnc2c1)-c1ccc(C#N)c(C)c1

InChI Key InChIKey=RXHXLESLBWUVQS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647340   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647340(4-(7-(1-ethyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyr...)
Affinity DataIC50:  0.855nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647340(4-(7-(1-ethyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyr...)
Affinity DataIC50:  8.34nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
The General Hospital

US Patent
LigandPNGBDBM647340(4-(7-(1-ethyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyr...)
Affinity DataIC50:  4.16nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent