BDBM647346 2-(4-(6-(1- cyclopropyl-1H- pyrazol-4- yl)pyrazolo[1,5- a]pyridin-3-yl)-2,6- dimethoxyphenyl)- 5-ethyl-1,3,4- oxadiazole::US20240025892, Example 53

SMILES CCc1nnc(o1)-c1c(OC)cc(cc1OC)-c1cnn2cc(ccc12)-c1cnn(c1)C1CC1

InChI Key InChIKey=XVNZURGXHLXJIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647346   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647346(2-(4-(6-(1- cyclopropyl-1H- pyrazol-4- yl)pyrazolo...)
Affinity DataIC50:  1.77nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647346(2-(4-(6-(1- cyclopropyl-1H- pyrazol-4- yl)pyrazolo...)
Affinity DataIC50:  17.4nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
The General Hospital

US Patent
LigandPNGBDBM647346(2-(4-(6-(1- cyclopropyl-1H- pyrazol-4- yl)pyrazolo...)
Affinity DataIC50:  2.62nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent