BDBM647350 2-ethyl-5-(2- methoxy-4-(7- (1-methyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyridin-3- yl)phenyl)- 1,3,4-oxadiazole::US20240025892, Example 57

SMILES CCc1nnc(o1)-c1ccc(cc1OC)-c1cnc2cc(ccn12)-c1cnn(C)c1

InChI Key InChIKey=ZGIZZXHFELWYTH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647350   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647350(2-ethyl-5-(2- methoxy-4-(7- (1-methyl-1H- pyrazol-...)
Affinity DataIC50:  8.76nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647350(2-ethyl-5-(2- methoxy-4-(7- (1-methyl-1H- pyrazol-...)
Affinity DataIC50:  90.8nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
The General Hospital

US Patent
LigandPNGBDBM647350(2-ethyl-5-(2- methoxy-4-(7- (1-methyl-1H- pyrazol-...)
Affinity DataIC50:  11nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent