BDBM647353 2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1H-pyrazol-4- yl)imidazo[1,2- a]pyridin-3- yl)phenyl)- 1,3,4-oxadiazole::US20240025892, Example 60

SMILES COc1cc(cc(OC)c1-c1nnc(o1)C1CC1)-c1cnc2cc(ccn12)-c1cnn(C)c1

InChI Key InChIKey=DEJPFOVGKKDPLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647353   

TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647353(2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1...)
Affinity DataIC50:  1.49nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM647353(2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1...)
Affinity DataIC50:  4.45nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
The General Hospital

US Patent
LigandPNGBDBM647353(2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1...)
Affinity DataIC50:  1.64nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent