BDBM770 4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl)-2H-pyran-2-one::CHEMBL22164::U-96988

SMILES CCC(Cc1ccccc1)c1cc(O)c(C(CC)c2ccccc2)c(=O)o1

InChI Key InChIKey=HALPINAQGOXQAN-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 770   

TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Upjohn

LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  32nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  38nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  38nMAssay Description:Binding affinity to HIV-1 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataKi:  38nMAssay Description:Compound was evaluated for in vitro inhibition of human immunodeficiency virus type 1 (HIV-1) ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)TBA
LigandPNGBDBM770(4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Compound was evaluated for in vitro inhibition of human immunodeficiency virus type 1 (HIV-1) ProteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed