BDBM81901 AF-DX 384::CAS_119356::CHEMBL279453::NSC_119356

SMILES CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2C(=O)Nc2cccnc12

InChI Key InChIKey=MZDYABXXPZNUCT-UHFFFAOYSA-N

Data  19 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 81901   

TargetMuscarinic acetylcholine receptor DM1(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  5.30nMAssay Description:Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  6nMAssay Description:Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details Article
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  6.03nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor DM1(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-NMS from human muscarinic M4 receptor expressed in stable CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  10nMAssay Description:Affinity for Muscarinic acetylcholine receptor M4 expressed in CHO cells by [3H]NMS displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details Article
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for displacement of [3H]QNB from human Muscarinic m1 receptor in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  30.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  31nMAssay Description:Affinity for Muscarinic acetylcholine receptor M1 expressed in CHO cells by [3H]NMS displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details Article
PubMed
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-NMS from human muscarinic M1 receptor expressed in stable CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]-NMS from human muscarinic M3 receptor expressed in stable CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  66nMAssay Description:Affinity for Muscarinic acetylcholine receptor M3 expressed in CHO cells by [3H]-NMS displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  66.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  537nMAssay Description:Displacement of [3H]-NMS from human muscarinic M5 receptor expressed in stable CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  537nMAssay Description:Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM81901(CHEMBL279453 | NSC_119356 | CAS_119356 | AF-DX 384)
Affinity DataKi:  537nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details
PubMed