BindingDB BDBM81982 CAS_97-39-2::DITOLYLGUANIDINE::DTG::Di-o-tolylguanidine::Tol2Gdn::cid

BDBM81982 CAS_97-39-2::DITOLYLGUANIDINE::DTG::Di-o-tolylguanidine::Tol2Gdn::cid_7333

SMILES Cc1ccccc1NC(N)=Nc1ccccc1C

InChI Key InChIKey=OPNUROKCUBTKLF-UHFFFAOYSA-N

Data 61 KI 15 IC50 3 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 81982

Sigma non-opioid intracellular receptor 1(RAT)
Kanazawa University

Curated by ChEMBL

BDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)

Ki: 131nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cerebral membrane after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article PubMed

Vesicular acetylcholine transporter(Rattus norvegicus)
Kanazawa University

Curated by ChEMBL

BDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)

Ki: 1.13E+3nMAssay Description:Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Patents Similars

Details Article PubMed

Filter my 79 hits

Targets 10▿
- Sigma non-opioid intracellular receptor 1 68
- 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 2
- 5-hydroxytryptamine receptor 3A 2
- C-8 sterol isomerase ERG2 1
- Protein Rev 1
- Female germline-specific tumor suppressor gld-1 1
- Nischarin 1
- Muscarinic acetylcholine receptor M2 1
- Muscarinic acetylcholine receptor M1 1
- Vesicular acetylcholine transporter 1
Publications 50▿
- J Med Chem 35: 4683-9 (1993) 4
- J Med Chem 37: 1964-70 (1994) 3
- J Med Chem 48: 4754-64 (2005) 3
- J Med Chem 51: 7523-31 (2009) 2
- J Pharmacol Exp Ther 267: 961-70 (1993) 2
- J Med Chem 38: 2009-17 (1995) 2
- J Med Chem 45: 2662-5 (2002) 2
- J Med Chem 45: 438-48 (2002) 2
- J Med Chem 33: 2421-9 (1990) 2
- Bioorg Med Chem Lett 4: 2185-2188 (1994) 2
- J Med Chem 48: 266-73 (2005) 2
- Bioorg Med Chem 20: 4936-41 (2012) 2
- J Pharm Pharmacol 38: 374-9 (1986) 2
- J Med Chem 45: 4923-30 (2002) 2
- J Med Chem 37: 1737-9 (1994) 2
- J Pharmacol Exp Ther 285: 170-7 (1998) 1
- J Med Chem 53: 4212-22 (2010) 1
- J Med Chem 50: 6144-53 (2007) 1
- Eur J Med Chem 44: 4306-14 (2009) 1
- Bioorg Med Chem 21: 1844-56 (2013) 1
- J Med Chem 36: 2311-20 (1993) 1
- J Med Chem 52: 5380-93 (2009) 1
- J Med Chem 52: 7817-28 (2009) 1
- Bioorg Med Chem 17: 777-93 (2009) 1
- J Med Chem 55: 8047-65 (2012) 1
- Bioorg Med Chem Lett 7: 2303-2306 (1997) 1
- J Med Chem 55: 5350-60 (2012) 1
- Eur J Med Chem 44: 124-30 (2008) 1
- Bioorg Med Chem 18: 4095-102 (2010) 1
- PubChem Bioassay (2010) 1
- Bioorg Med Chem 18: 8005-15 (2010) 1
- Eur J Med Chem 42: 1247-62 (2007) 1
- J Med Chem 43: 177-89 (2000) 1
- J Med Chem 34: 1855-9 (1991) 1
- Eur J Med Chem 69: 490-7 (2013) 1
- J Med Chem 37: 260-7 (1994) 1
- Eur J Med Chem 64: 488-97 (2013) 1
- J Med Chem 52: 2126-37 (2009) 1
- Eur J Med Chem 46: 1972-82 (2011) 1
- Bioorg Med Chem Lett 3: 2113-2116 (1993) 1
- J Med Chem 47: 2308-17 (2004) 1
- J Med Chem 51: 6531-7 (2008) 1
- Eur J Med Chem 44: 519-25 (2009) 1
- Bioorg Med Chem 17: 3630-41 (2009) 1
- Bioorg Med Chem 16: 2992-3001 (2008) 1
- J Med Chem 37: 314-21 (1994) 1
- J Med Chem 54: 3669-73 (2011) 1
- J Pharmacol Exp Ther 289: 251-60 (1999) 1
- Bioorg Med Chem 17: 1445-55 (2009) 1
- J Med Chem 39: 176-82 (1996) 1
- ...
Institutions 38▿
- TBA 6
- National Institute On Drug Abuse 4
- University Of Catania 3
- Albany Molecular Research 3
- Universit£ 3
- University Of Innsbruck 3
- Universita Degli Studi Di Bari 3
- Syntex Discovery Research 2
- Kanazawa University 2
- University Of Oregon 2
- Institut F£R Pharmazeutische Und Medizinische Chemie 2
- H. Lundbeck 2
- Wilhelms-Universit£T M£Nster 2
- University Of Trieste 2
- George Washington University Medical Center 2
- Pharmazeutisches Institut Der UniversitäT Freiburg 2
- Pharmazeutisches Institut Der Universit£T Freiburg 2
- Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster 2
- Institut FüR Pharmazeutische Und Medizinische Chemie Der WestfäLischen Wilhelms-UniversitäT MüNster 2
- Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster 2
- Institut FüR Pharmazeutische Und Medizinische Chemie 1
- Westf£Lische Wilhelms-Universit£T M£Nster 1
- Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhems-Universit£T M£Nster 1
- University of Bonn 1
- Universit£T M£Nster 1
- Nstri 1
- National Institutes Of Diabetes And Digestive And Kidney Diseases 1
- Cambridge Neuroscience 1
- National Institute Of Diabetes And Digestive And Kidney Diseases 1
- The Scripps Research Institute Molecular Screening Center 1
- Institut FüR Pharmazeutische And Medizinische Chemie Der UniversitäT MüüNster 1
- Institut FüR Pharmazeutische Und Medizinische Chemie Der UniversitäT MüNster 1
- Institut Fur Pharmazeutische Und Medizinische Chemie Der Westfalischen Wilhelms-Universitat Munster 1
- Virginia Commonwealth University 1
- Università 1
- Medical College of Georgia 1
- Otsuka Pharmaceutical 1
- University M£Nster 1
- ...
Affinity: 12 to 8.3E+3 nM▿
- Ki 61
- IC50 15
- Kd 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1