BDBM8225 3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6h

SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2Cl)c1

InChI Key InChIKey=OBJPHIOAHHIJPG-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8225   

TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
University Of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8225(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Affinity DataKi:  28nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 10(Homo sapiens (Human))
University Of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8225(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Affinity DataKi:  310nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8225(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Affinity DataIC50:  195nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM8225(3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-2,5-d...)
Affinity DataIC50:  195nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed