BDBM8808 3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine::Pyrazolo[3,4-d]pyrimidine 16

SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(NCc3cc4ccccc4[nH]3)cc2)c2c(N)ncnc12

InChI Key InChIKey=DTAHSAPUHXWXSX-DIVCQZSQSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8808   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8808(3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-m...)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8808(3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-m...)
Affinity DataIC50:  203nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8808(3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-m...)
Affinity DataIC50:  435nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

LigandPNGBDBM8808(3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-m...)
Affinity DataIC50:  526nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed