BDBM8870 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-chlorophenyl)urea::CHEMBL382979::KDR Kinase Inhibitor, 9::N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-chlorophenyl)urea::Thienopyrimidine deriv. 96

SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12

InChI Key InChIKey=WALBWDUVJYSLBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8870   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8870(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Affinity DataIC50:  3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8870(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Affinity DataIC50:  3.02nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8870(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM8870(3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed