BDBM8881 5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)methyl]-1H-imidazole::5-{[(1E)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]methyl}-1H-imidazole::Imidazolylmethyleneindane 8a::Imidazolylmethyleneindane 8b

SMILES Clc1ccc2C(CCc2c1)=Cc1cnc[nH]1

InChI Key InChIKey=FGJKKMYLQYGVLE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8881   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  28.7nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  19.5nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  88.8nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  330nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  39nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8881(5-[(E)-(5-Chloro-2,3-dihydro-1H-inden-1-ylidene)me...)
Affinity DataIC50:  3.70nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed