BDBM9920 (S)Fadrozole::4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile::4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl]benzonitrile::CHEMBL31215
SMILES N#Cc1ccc(cc1)[C@@H]1CCCc2cncn12
InChI Key InChIKey=CLPFFLWZZBQMAO-AWEZNQCLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 9920
Affinity DataIC50: 17nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human CYP11B2 expressed in V79 cells using 11-deoxycorticosteron as substrate preincubated for 1 hr followed by substrate addition and ...More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human aldosterone synthase expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticost...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Eindhoven University Of Technology
Curated by ChEMBL
Eindhoven University Of Technology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of human CYP11B1 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Guangzhou University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 171nMAssay Description:Inhibition of human CYP11B2 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Eindhoven University Of Technology
Curated by ChEMBL
Eindhoven University Of Technology
Curated by ChEMBL
Affinity DataIC50: 171nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZ cells pretreated with compound for 1 hr followed by addition of 500 nM 11-deoxycorticosterone for 3 h...More data for this Ligand-Target Pair