Compile Data Set for Download or QSAR
Report error Found 1033 Enz. Inhib. hit(s) with Target = 'Activated CDC42 kinase 1'
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621875(CHEMBL5400397)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421256(CHEMBL2087874)
Affinity DataKi:  0.200nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421257(CHEMBL2087875)
Affinity DataKi:  0.300nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621877(CHEMBL5408748)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421256(CHEMBL2087874)
Affinity DataKi:  0.300nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421255(CHEMBL2087873)
Affinity DataKi:  0.300nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621883(CHEMBL5431206)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621855(CHEMBL5409024)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621858(CHEMBL5398945)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621888(CHEMBL5419830)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621880(CHEMBL5428907)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621878(CHEMBL5405674)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621884(CHEMBL5399309)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621876(CHEMBL5437496)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621882(CHEMBL5439245)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419721(US10464919, Example 59)
Affinity DataIC50: 0.920nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419799(US10464919, Example 137)
Affinity DataIC50: 0.950nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50204580(N-phenethyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621881(CHEMBL5436567)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621879(CHEMBL5434969)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419844(US10464919, Example 182)
Affinity DataIC50: 1.26nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621862(CHEMBL5431312)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419794(US10464919, Example 132)
Affinity DataIC50: 1.31nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419731(US10464919, Example 69)
Affinity DataIC50: 1.32nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419781(US10464919, Example 119)
Affinity DataIC50: 1.38nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419751(US10464919, Example 89)
Affinity DataIC50: 1.48nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419791(US10464919, Example 129)
Affinity DataIC50: 1.65nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419758(US10464919, Example 96)
Affinity DataIC50: 1.75nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419797(US10464919, Example 135)
Affinity DataIC50: 1.75nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419740(US10464919, Example 78)
Affinity DataIC50: 1.87nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621871(CHEMBL5404048)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419832(US10464919, Example 170)
Affinity DataIC50: 1.96nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419755(US10464919, Example 93)
Affinity DataIC50: 1.97nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419761(US10464919, Example 99)
Affinity DataIC50: 1.99nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50245854(N3-(2,6-dichlorophenyl)-N6-(3-fluoro-4-(2-(pyrroli...)
Affinity DataKi:  2nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421286(CHEMBL2087662)
Affinity DataKi:  2nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  2nMAssay Description:Binding constant for TNK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50246162(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataKi:  2nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421278(CHEMBL2087654)
Affinity DataKi:  2nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50421276(CHEMBL2087652)
Affinity DataKi:  2nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50246164(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50337126(US9266890, IV-2 | CHEMBL1672987 | Scaffold, B19 | ...)
Affinity DataKd:  2nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50246214(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataKi:  2nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50621890(CHEMBL5415503)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 (117 to 389 residues) (unknown origin) expressed in Sf9 cells using ATP as substrate incubated for 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419765(US10464919, Example 103)
Affinity DataIC50: 2.10nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419842(US10464919, Example 180)
Affinity DataIC50: 2.12nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419784(US10464919, Example 122)
Affinity DataIC50: 2.37nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419785(US10464919, Example 123)
Affinity DataIC50: 2.38nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

TargetActivated CDC42 kinase 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM419804(US10464919, Example 142)
Affinity DataIC50: 2.45nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
US Patent

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