Compile Data Set for Download or QSAR
Report error Found 4939 Enz. Inhib. hit(s) with Target = 'Aurora kinase A'
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DatapH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.60E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd:  590nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  7.40E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  2.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  7.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  250nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM31093(cid_11712649 | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-...)
Affinity DataKd:  6.5nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  120nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  110nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  4.10nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM109206(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-[(4- ...)
Affinity DataKd:  0.273nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM109207(Compound II: Ac-D-Arg6-D-Lys(PromoFluor 647)-D-Lys...)
Affinity DataKd:  5.20nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM109208(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-{[4- ...)
Affinity DataKd:  0.200nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109206(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-[(4- ...)
Affinity DataKd:  0.527nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109207(Compound II: Ac-D-Arg6-D-Lys(PromoFluor 647)-D-Lys...)
Affinity DataKd:  4.34nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109208(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-{[4- ...)
Affinity DataKd:  0.544nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  7.5nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50602900(CHEMBL5185704 | US11814388, Compound 3)
Affinity DataKd:  3.50E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  3.40E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM635490(US11814388, Compound 5)
Affinity DataKd:  1.60E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM635491(US11814388, Compound 6)
Affinity DataKd:  2.10E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM635492(US11814388, Compound 7)
Affinity DataKd:  1.60E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM635493(US11814388, Compound 8)
Affinity DataKd:  1.20E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd: >3.00E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataKd:  240nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50453821(CHEMBL4206831)
Affinity DataEC50:  38nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataEC50:  106nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50456107(CHEMBL4204878)
Affinity DataKd:  100nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50004205(MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...)
Affinity DataKd:  0.501nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50456108(CHEMBL4216458)
Affinity DataKd:  40nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50456110(CHEMBL4216563)
Affinity DataKd:  5.01E+3nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50456111(CHEMBL4217093)
Affinity DataKd:  50nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50456109(CHEMBL4212119)
Affinity DataKd:  25nMAssay Description:Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50460773(CHEMBL4227082)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to Aurora A (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50460772(CHEMBL4225923)
Affinity DataKd:  0.0100nMAssay Description:Binding affinity to Aurora A (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  45nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged AURKA (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  51nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged AURKA (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM87047(Bisanilinopyrimidine, 3h | Bisanilinopyrimidine in...)
Affinity DataKd:  39nMAssay Description:Binding affinity to His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM87052(Bisanilinopyrimidine, 6a | Bisanilinopyrimidine in...)
Affinity DataKd:  16nMAssay Description:Binding affinity to His6 tagged MBP fused human aurora A (123 to 390 residues) expressed in Escherichia coli Tuner (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  23nMAssay Description:Binding affinity to wild-type human partial length AURKA (E122 to K401 residues) expressed in mammalian expression system measured after 1 hr by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM324284((R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4...)
Affinity DataKd:  660nMAssay Description:Binding affinity to wild-type human partial length AURKA (E122 to K401 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50587891(CHEMBL5181237 | US11814388, Compound 4)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to DNA-tagged Aurora A (unknown origin) expressed in mammalian system assessed as binding constant (Kd) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  16nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  980nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.80E+3nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  6.60E+3nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM50401421(CHEMBL2207503)
Affinity DataKd:  7.5nMAssay Description:Binding affinity to Aurora A (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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