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Report error Found 73 Enz. Inhib. hit(s) with Target = 'Bile salt-activated lipase'
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081700(6-Chloro-3-(2-cyclohexyl-ethyl)-pyran-2-one | CHEM...)
Affinity DataKi:  25nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081696(6-Chloro-3-cyclopentyl-pyran-2-one | CHEMBL133091)
Affinity DataKi:  40nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081698(6-Chloro-5-(2-cyclohexyl-ethyl)-pyran-2-one | CHEM...)
Affinity DataKi:  58nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081697(6-Chloro-3-(3-cyclohexyl-propyl)-pyran-2-one | CHE...)
Affinity DataKi:  60nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM24567(Tetrahydrolipstatin | CHEMBL175247 | Xenical | (2S...)
Affinity DataIC50: 423nMAssay Description:Inhibition of Sus scrofa (pig) pancreatic lipase type 2 using PNPB as substrate pre-incubated with enzyme for 5 min prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

LigandPNGBDBM50084233(2-Diethylamino-6,7-dihydro-5H-cyclopenta[4,5]thien...)
Affinity DataKi:  580nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081695(6-Chloro-3-(4-cyclohexyl-butyl)-pyran-2-one | CHEM...)
Affinity DataKi:  580nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179322(6,7-dihydro-2-(dimethylamino)-4H,5H-cyclopenta[4,5...)
Affinity DataKi:  630nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50286878(Butyl-carbamic acid 2'-hydroxy-[1,1']binaphthaleny...)
Affinity DataKi:  800nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50286878(Butyl-carbamic acid 2'-hydroxy-[1,1']binaphthaleny...)
Affinity DataKi:  800nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50286878(Butyl-carbamic acid 2'-hydroxy-[1,1']binaphthaleny...)
Affinity DataKi:  800nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50084229(2-Diethylamino-5-methyl-5,6,7,8-tetrahydro-benzo[4...)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50064308(2-Diethylamino-5,6,7,8-tetrahydro-benzo[4,5]thieno...)
Affinity DataKi:  1.86E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179331(5,6,7,8-tetrahydro-2-(dimethylamino)-4H-benzo[4,5]...)
Affinity DataKi:  2.15E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081694(6-Chloro-3-cyclohexylmethyl-pyran-2-one | CHEMBL44...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50081699(6-Chloro-3-cyclohexyl-pyran-2-one | CHEMBL134790)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of the Pancreatic Cholesterol Esterase from porcineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179326(2-Diethylamino-5,6-dimethyl-thieno[2,3-d][1,3]oxaz...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179329(2-morpholin-4-yl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  5.70E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179318(2-dimethylamino-5,8-dihydro-4H,6H-thiopyrano[4',3'...)
Affinity DataKi:  5.76E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50084234(2-Diethylamino-6,7,8,9-tetrahydro-5H-3-oxa-10-thia...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50084232(2-Diethylamino-5-isopropyl-thieno[2,3-d][1,3]oxazi...)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50084235(2-Diethylamino-benzo[4,5]thieno[2,3-d][1,3]oxazin-...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50286880(Butyric acid 2'-butylcarbamoyloxy-[1,1']binaphthal...)
Affinity DataKi:  9.00E+3nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetBile salt-activated lipase(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50244756(2-(2,3,5,6-Tetrafluoropyridin-4-yl)-1,2-benzisothi...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of cholesterol esteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50084228(2-(diethylamino)-5-methyl-4H-thieno[2,3-d][1,3]oxa...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179311(2-(cyclohexyl-methyl-amino)-5,6,7,8-tetrahydro-ben...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50286880(Butyric acid 2'-butylcarbamoyloxy-[1,1']binaphthal...)
Affinity DataKi:  2.00E+4nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50286880(Butyric acid 2'-butylcarbamoyloxy-[1,1']binaphthal...)
Affinity DataKi:  2.00E+4nMAssay Description:Bimolecular rate constant (ki) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50480308(Dihydroberberine)
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of Sus scrofa (pig) pancreatic lipase type 2 using PNPB as substrate pre-incubated with enzyme for 5 min prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

LigandPNGBDBM50286879(Butyl-carbamic acid 2'-butylcarbamoyloxy-[1,1']bin...)
Affinity DataKi:  2.90E+4nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50286879(Butyl-carbamic acid 2'-butylcarbamoyloxy-[1,1']bin...)
Affinity DataKi:  3.00E+4nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50286879(Butyl-carbamic acid 2'-butylcarbamoyloxy-[1,1']bin...)
Affinity DataKi:  3.00E+4nMAssay Description:Dissociation constant (KI) for the Pancreatic cholesterol esterase-catalyzed hydrolysis of 4-nitrophenyl butyrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50179327(7-benzyl-5,6,7,8-tetrahydro-2-phenylamino-4H-pyrid...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179321(7-benzoyl-5,6,7,8-tetrahydro-2-(dimethylamino)-4H-...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179308(7-benzyl-5,6,7,8-tetrahydro-2-(morpholin-4-yl)-4H-...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179309(7-benzyl-5,6,7,8-tetrahydro-2-isopropylamino-4H-py...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50084227(2-Diethylamino-5-methyl-4-oxo-4H-thieno[2,3-d][1,3...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179310(2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido[4',3...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179313(2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido[4',3...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50064321(2-isopropylamino-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179325(7-benzyl-2-(N-benzyl-N-methyl-amino)-5,6,7,8-tetra...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179316(5,8-dihydro-2-(dimethylamino)-4H,6H-pyrano[4',3':4...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179314(5,6,7,8-tetrahydro-2-(dimethylamino)-7-(2-methyl-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179330(2-benzoylamino-7-benzyl-5,6,7,8-tetrahydro-4H-pyri...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179312(7-benzyl-5,6,7,8-tetrahydro-2-(dimethylamino)-4H-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179328(7-benzyl-5,6,7,8-tetrahydro-2-[N-3,4-dimethoxy-ben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179319(7-benzyl-2-cyclohexylamino-5,6,7,8-tetrahydro-4H-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179320(7-benzyl-5,6,7,8-tetrahydro-2-phenylamino-4H-pyrid...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179332(7-benzyl-2-cyclohexylamino-5,6,7,8-tetrahydro-4H-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50179333(5,6,7,8-tetrahydro-7-methyl-2-(dimethylamino)-4H-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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