Compile Data Set for Download or QSAR
Report error Found 592 Enz. Inhib. hit(s) with Target = 'Bone morphogenetic protein receptor type-1B'
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human BMPR1B assessed as dissociation constant by Adp-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  0.850nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  2.10nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  4nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 12.7nMAssay Description:Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148348(US9682983, 22 | US10017516, Compound 22)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50645759(CHEMBL5590317)
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148348(US9682983, 22 | US10017516, Compound 22)
Affinity DataIC50: 15nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50560466(CHEMBL4740381)
Affinity DataIC50: 18nMAssay Description:Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 107nM Kd:  19nMAssay Description:Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 22nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 22nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50560467(CHEMBL4788859)
Affinity DataIC50: 29nMAssay Description:Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143282(US9682983, 10 | US10017516, Compound 10)
Affinity DataIC50: 38nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143282(US9682983, 10 | US10017516, Compound 10)
Affinity DataIC50: 38nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50463507(CHEMBL4247751)
Affinity DataKd:  39nMAssay Description:Binding affinity to human ALK6 by KdELECT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50560468(CHEMBL4786529)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50645749(CHEMBL5083143)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM36354(DMH1 | 4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 48nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataEC50:  50nMAssay Description:Inhibition of ALK6 NanoLuc fusion construct (unknown origin) incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143566(US9682983, 13 | US10017516, Compound 13)
Affinity DataIC50: 51nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143566(US9682983, 13 | US10017516, Compound 13)
Affinity DataIC50: 51nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148353(US9682983, 24 | US10017516, Compound 24)
Affinity DataIC50: 52nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148353(US9682983, 24 | US10017516, Compound 24)
Affinity DataIC50: 52nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  53nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50560477(CHEMBL4742906)
Affinity DataIC50: 55nMAssay Description:Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50262016(4-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Affinity DataIC50: 57nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  57nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  57nMAssay Description:Binding affinity to BMPR1BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 60nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50434751(CHEMBL2385579)
Affinity DataIC50: 61nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50528194(CHEMBL4517408)
Affinity DataIC50: 68nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50645536(CHEMBL5591770)
Affinity DataIC50: 82nMAssay Description:Inhibition of ALK6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50: 88nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM102618(LDN-212854)
Affinity DataIC50: 93nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50463510(CHEMBL4244382)
Affinity DataKd:  96nMAssay Description:Binding affinity to human ALK6 by KdELECT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50434748(CHEMBL2385600)
Affinity DataIC50: 102nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148349(US9682983, 23 | US10017516, Compound 23)
Affinity DataIC50: 106nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148349(US9682983, 23 | US10017516, Compound 23)
Affinity DataIC50: 106nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  120nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50645751(CHEMBL5595157)
Affinity DataIC50: 123nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50434749(CHEMBL2385586)
Affinity DataIC50: 129nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148356(US9682983, 27 | US10017516, Compound 27)
Affinity DataIC50: 140nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM148356(US9682983, 27 | US10017516, Compound 27)
Affinity DataIC50: 140nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143313(US9682983, 12 | US10017516, Compound 12)
Affinity DataIC50: 150nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM143313(US9682983, 12 | US10017516, Compound 12)
Affinity DataIC50: 150nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

LigandPNGBDBM518855(US11160797, Example 26 | US11160797, Example 28 | ...)
Affinity DataIC50: 160nMAssay Description:Example 54:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  170nMAssay Description:Binding constant for BMPR1B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
Southern University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM161913(US9682983, 45 | US10017516, Compound 45)
Affinity DataIC50: 184nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

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