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Report error Found 17524 Enz. Inhib. hit(s) with Target = 'Coagulation factor X'
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23534(6-methyl-2-oxo-N-(propan-2-yl)-2H-chromene-3-carbo...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23535(N-cyclohexyl-6-methyl-2-oxo-2H-chromene-3-carboxam...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23550(8-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23551(5-oxo-N-phenyl-6-oxatricyclo[8.4.0.0^{2,7}]tetrade...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23552(7-hydroxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23553(7-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23554(7-(diethylamino)-2-oxo-N-phenyl-2H-chromene-3-carb...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23561(phenyl 2-oxo-2H-chromene-3-carboxylate | 3-Carboxy...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23562(phenyl 6-methyl-2-oxo-2H-chromene-3-carboxylate | ...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23564(N-(3,5-dimethylphenyl)-6-methyl-2-oxo-2H-chromene-...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23547(6,8-dichloro-2-oxo-N-phenyl-2H-chromene-3-carboxam...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23565(6,8-dichloro-N-(3-methylphenyl)-2-oxo-2H-chromene-...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23548(8-bromo-6-chloro-2-oxo-N-phenyl-2H-chromene-3-carb...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23567(8-bromo-6-chloro-N-(3-methylphenyl)-2-oxo-2H-chrom...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23536(N-cyclododecyl-6-methyl-2-oxo-2H-chromene-3-carbox...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23537(N-(adamantan-1-yl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23538(6-methyl-2-oxo-N-phenyl-2H-chromene-3-carboxamide ...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23539(N-benzyl-6-methyl-2-oxo-2H-chromene-3-carboxamide ...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23540(6-methyl-2-oxo-N-(2-phenylethyl)-2H-chromene-3-car...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23541(6-methyl-N-(naphthalen-1-ylmethyl)-2-oxo-2H-chrome...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23542(6-methyl-2-oxo-N-(quinolin-3-yl)-2H-chromene-3-car...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23543(2-oxo-N-phenyl-2H-chromene-3-carboxamide | JMC5219...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23545(6-nitro-2-oxo-N-phenyl-2H-chromene-3-carboxamide |...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23546(6-bromo-2-oxo-N-phenyl-2H-chromene-3-carboxamide |...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23549(6-bromo-8-methoxy-2-oxo-N-phenyl-2H-chromene-3-car...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23555(N-(2-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23556(N-(3-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23557(N-(4-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23558(6-methyl-N-(2-methylphenyl)-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23559(6-methyl-N-(3-methylphenyl)-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM23560(6-methyl-N-(4-methylphenyl)-2-oxo-2H-chromene-3-ca...)
Affinity DataAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458533(CHEMBL4206890)
Affinity DataKd:  1.40E+6nMAssay Description:Inhibition of human factor 11a assessed as reduction in para-nitroanilide releasee using pyroGlu-Pro-Arg-pNA.HCl substrate by by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537826(CHEMBL4645930)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to factor 10a (unknown origin) assessed as dissociation rate constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537827(CHEMBL4635562)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to factor 10a (unknown origin) assessed as dissociation rate constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537828(CHEMBL4635937)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to factor 10a (unknown origin) assessed as dissociation rate constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537826(CHEMBL4645930)
Affinity DataKd:  7.5nMAssay Description:Binding affinity to factor 10a (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537827(CHEMBL4635562)
Affinity DataKd:  8.40nMAssay Description:Binding affinity to factor 10a (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50537828(CHEMBL4635937)
Affinity DataKd:  10nMAssay Description:Binding affinity to factor 10a (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124992(N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-...)
Affinity DataKon:  0.0130M-1s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124984((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataKon:  3.10M-1s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124972(N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[4...)
Affinity DataKon:  0.132M-1s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124984((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataKon:  3.10M-1s-1 Koff:  0.00000700s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124995(2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-...)
Affinity DataKoff:  0.00000300s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124992(N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-...)
Affinity DataKoff:  0.00000200s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124990(N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2...)
Affinity DataKoff:  0.00000300s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124995(2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-...)
Affinity DataKon:  0.190M-1s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124990(N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2...)
Affinity DataKon:  0.107M-1s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Namur

LigandPNGBDBM50124972(N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[4...)
Affinity DataKoff:  0.00000600s-1Assay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50580355(CHEMBL5093463)
Affinity DataEC50:  8.5nMAssay Description:Inhibition of human coagulation factor 11 assessed as inhibition of factor 12a mediated activation using z-GPR-AFC measured after 60 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50580356(CHEMBL5079764)
Affinity DataEC50:  19nMAssay Description:Inhibition of human coagulation factor 11 assessed as inhibition of factor 12a mediated activation using z-GPR-AFC measured after 60 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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