Compile Data Set for Download or QSAR
Report error Found 539 Enz. Inhib. hit(s) with Target = 'Cyclin-K/Cyclin-dependent kinase 12'
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724589(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 3.09nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724595(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 4.14nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724593(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 5.96nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724587(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 7.59nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724585(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 8.34nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724586(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 9.21nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724596(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 11.9nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729623(US20250101023, Example 49)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724590(N-{[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl}-2...)
Affinity DataIC50: 12.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724599(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 15.1nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729620(US20250101023, Example 46)
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729624(US20250101023, Example 50)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724584(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 26.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729626(US20250101023, Example 53)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724588(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 32.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724581(8-bromo-2-(morpholin-4-yl)-N-({5-[4-(trifluorometh...)
Affinity DataIC50: 34.8nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724594(N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-y...)
Affinity DataIC50: 41.6nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM50528813(CHEMBL4163879 | US20250101023, Example THZ531)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729597(US20250101023, Example 20)
Affinity DataIC50: 51nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729610(US20250101023, Example 35)
Affinity DataIC50: 53nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729625(US20250101023, Example 51)
Affinity DataIC50: 56nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729595(US20250101023, Example 18)
Affinity DataIC50: 65nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729627(US20250101023, Example 54)
Affinity DataIC50: 77nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724592(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 79.1nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729612(US20250101023, Example 37)
Affinity DataIC50: 86nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729598(US20250101023, Example 21)
Affinity DataIC50: 87nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729594(US20250101023, Example 17)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM729596(US20250101023, Example 19)
Affinity DataIC50: 94nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478961((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478963(US10894788, Example 3 | US10894788, Example 65 | (...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478965(US10894788, Example 5 | US10894788, Example 66 | (...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478966(US10894788, Example 6 | US10894788, Example 72 | (...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478967(US10894788, Example 7 | US10894788, Example 67 | (...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM479038((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478970(US10894788, Example 10 | US10894788, Example 68 | ...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478971(US10894788, Example 11 | (R)-N-(4-(3-((5-chloro-4-...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478974((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478974((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478979((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478979((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478980((R)-N-(4-(3-((5-bromo-4- methoxypyrimidin-2- yl)am...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478981(US10894788, Example 21 | US10894788, Example 56 | ...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478984((R)-N-(4-(3-((5-chloro-4-(2,2,2- trifluoroethoxy)p...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478985((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478985((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478986((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM478986((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

Displayed 1 to 50 (of 539 total ) | Next | Last >>
Jump to: