Compile Data Set for Download or QSAR
Report error Found 174 Enz. Inhib. hit(s) with Target = 'Ephrin type-A receptor 1'
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human EPHA1 using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of EphA1 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  4.10nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  4.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  4.10nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  6.20nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  6.5nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50273637(3-(4-amino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  15nMAssay Description:Binding affinity to human EPHA1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  26nMAssay Description:Binding affinity to human EPHA1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant GST-tagged EPHA1 cytoplasmic domain (568 to 976 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2018
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHA1 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  39nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 50nMAssay Description:Inhibition of EPHA1 (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  67nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50330905(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50: 95nMAssay Description:Inhibition of EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 95.3nMAssay Description:Inhibition of human EPHA1 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  99nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50647988(CHEMBL5598020)
Affinity DataIC50: 110nMAssay Description:Inhibition of EphA1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human EPHA1 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  140nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 143nMAssay Description:Binding affinity to human EPHA1 using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 145nMAssay Description:Inhibition of full length NanoLuc fused EPHA1 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human wild type EPHA1 using PolyEY as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  150nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  230nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  230nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  230nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50592745(CHEMBL5188373)
Affinity DataIC50: 292nMAssay Description:Inhibition of EphA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  300nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  300nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  300nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50584948(CHEMBL5092606)
Affinity DataIC50: 303nMAssay Description:Inhibition of human recombinant EPHA1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataIC50: 303nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHA1 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  380nMAssay Description:Binding affinity to EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  380nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50584949(CHEMBL5089164)
Affinity DataIC50: 393nMAssay Description:Inhibition of human recombinant EPHA1 incubated for 1 hrs by HTRF KinEASE TK assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  586nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged EPHA1 (unknown origin) (586 to 976 residues) expressed in baculovirus infe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  588nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged EPHA1 (unknown origin) (586 to 976 residues) expressed in baculovirus infe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50237710(AMN 107 | AMN107 | 4-methyl-N-[3-(4-methyl-1H-imid...)
Affinity DataKd:  590nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 630nMAssay Description:Inhibition of EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50358591(CHEMBL1923983)
Affinity DataIC50: 686nMAssay Description:Inhibition of EPHA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  730nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EPHA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EPHA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human EPHA1 using poly (Glu, Tyr)4:1 as substrate in presence of [gamma33P]-ATP by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  1.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetEphrin type-A receptor 1(Human)TBA
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding constant for EPHA1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
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