Compile Data Set for Download or QSAR
Report error Found 192 Enz. Inhib. hit(s) with Target = 'Ephrin type-B receptor 3'
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataIC50: 6nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHB3 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  6.90nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssayPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  6.90nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  6.90nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50598820(CHEMBL5191665)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of EphB3 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHB3 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50598810(CHEMBL5202826)
Affinity DataIC50: 18nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50538442(CHEMBL4638981)
Affinity DataIC50: 20nMAssay Description:Inhibition of EPHB3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  29nMAssay Description:Binding affinity to human EPHB3 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 51nMAssay Description:Inhibition of EPHB3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311312(N-(2-chlorophenyl)-6-phenylimidazo[1,2-a]pyridine-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311306(N-(2-chlorophenyl)-5-(piperidin-1-yl)pyrazolo[1,5-...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311302(N-(2-chlorophenyl)-5-phenylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 66nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311303(N-(2-chlorophenyl)-5-(dimethylamino)pyrazolo[1,5-a...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311316(LDN-211904 | N-(2-chlorophenyl)-6-(piperidin-4-yl)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM26145(CHEMBL249097 | 3-({4-[(5-hydroxy-2-methylphenyl)am...)
Affinity DataKd:  81nMAssay Description:Binding affinity to human EPHB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  85nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311313(N-(2-chlorophenyl)-6-(piperidin-1-yl)imidazo[1,2-a...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311318(6-bromo-N-(2-chlorophenyl)-2-methylimidazo[1,2-a]p...)
Affinity DataIC50: 173nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311301(N-(2-chlorophenyl)-5-methoxypyrazolo[1,5-a]pyridin...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataIC50: 191nMAssay Description:Inhibition of Nano Luc-fused full length C-terminal EPHB3 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311304(N-(2-chlorophenyl)-5-(1H-pyrrol-1-yl)pyrazolo[1,5-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  210nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311317(N-(2-chlorophenyl)-6-(4-hydroxypiperidin-4-yl)imid...)
Affinity DataIC50: 228nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311305(N-(2-chlorophenyl)-5-morpholinopyrazolo[1,5-a]pyri...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311296(N-(2-chlorophenyl)-5-methylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  340nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50357333(CHEMBL1916891)
Affinity DataIC50: 350nMAssay Description:Inhibition of EPHB3 relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311311(N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxa...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 741nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50237710(AMN 107 | AMN107 | 4-methyl-N-[3-(4-methyl-1H-imid...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EPHB3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EPHB3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311288(N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carbox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human wild type EPHB3 using PolyEY as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50363957(CHEMBL1952210)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of EphB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibitory activity against EphB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for EPHB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50205468((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EPHB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50311299(5-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50205477((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EPHB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)TBA
LigandPNGBDBM50205472(CHEMBL393929 | CHEMBL261644 | (Z)-5-(quinolin-6-yl...)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EPHB3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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