Report error Found 2020 Enz. Inhib. hit(s) with Target = 'Epithelial discoidin domain-containing receptor 1'
Affinity DataKd: 0.200nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.200nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 0.400nMAssay Description:Binding affinity to DDR1 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of DDR1b (unknown origin) assessed as reduction in collagen-induced DDR1b activationMore data for this Ligand-Target Pair
Affinity DataKd: 0.600nMAssay Description:Binding affinity to DDR1 ATP binding site (unknown origin) after 1 hr by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.690nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.690nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.690nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.690nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.690nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.690nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.700nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.700nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.700nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.708nMAssay Description:Inhibition of FLAG-tagged DDR1 in human HEK293 cells assessed as reduction in collagen-1-induced DDR1 phosphorylation incubated for 18 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 0.794nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.10nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.5nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Binding affinity to DDR1More data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 1.52nMAssay Description:1× kinase base buffer (50 mM HEPES, pH 7.5, 0.0015% Brij-35) and a stop buffer (100 mM HEPES, pH 7.5, 0.015% Brij-35, 0.2% Coating Reagent #3, 50 mM ...More data for this Ligand-Target Pair
Affinity DataKd: 1.70nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.80nMAssay Description:Binding affinity to wild-type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.90nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Binding affinity to DDR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.20nMAssay Description:Binding affinity to DDR1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 2.20nMAssay Description:Binding affinity to human DNA-tagged DDR1 expressed in bacterial expression system measured after 1 hr by quantitative PCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.26nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of DDR1 (unknown origin) using Fluorescein-Poly GAT as substrate by TR-FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 2.56nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.15nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR1 (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMpH: 7.5 T: 2°CAssay Description:The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...More data for this Ligand-Target Pair
Affinity DataKd: 3.40nMAssay Description:KINOMEscan (Ambit Biosciences, San Diego, Calif.), a high-throughput method for screening small molecular agents against a large panel of human kinas...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair




3D Structure (crystal)


























