Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with Target = 'Exportin-1'
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50: 1nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataEC50:  2nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640051(CHEMBL5555068)
Affinity DataEC50:  4nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640055(CHEMBL5559223)
Affinity DataEC50:  4nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640043(CHEMBL5556912)
Affinity DataEC50:  4nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50619732(CHEMBL3898452)
Affinity DataEC50:  5nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640051(CHEMBL5555068)
Affinity DataEC50:  6nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640022(CHEMBL5568605)
Affinity DataEC50:  7nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245476(CHEMBL4088268)
Affinity DataIC50: 10nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640032(CHEMBL5542885)
Affinity DataEC50:  11nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataEC50:  12nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640036(CHEMBL5566091)
Affinity DataEC50:  13nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50619732(CHEMBL3898452)
Affinity DataIC50: 16nMAssay Description:Inhibition of XPO1 in human HPBALL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640020(CHEMBL5560534)
Affinity DataEC50:  19nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640031(CHEMBL5564554)
Affinity DataEC50:  21nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640042(CHEMBL5563530)
Affinity DataEC50:  23nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640021(Verdinexor | KPT-335)
Affinity DataEC50:  24nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50581761(CHEMBL5093328)
Affinity DataKd:  24nMAssay Description:Binding affinity to Cy3 dye-labelled human CRM1 assessed as dissociation constant in absence of RanGTP at 10 uM incubated for 1 hr by micro-scale the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640029(CHEMBL5562376)
Affinity DataEC50:  24nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640050(CHEMBL5542505)
Affinity DataEC50:  25nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245473(CHEMBL4077955)
Affinity DataIC50: 25nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640041(CHEMBL5542934)
Affinity DataEC50:  26nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527779(CHEMBL4440028)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 34nMAssay Description:Inhibition of XPO1 in human MOLT-16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640028(CHEMBL5561373)
Affinity DataEC50:  40nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640023(CHEMBL130837)
Affinity DataEC50:  48nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio | US20240376114, Comp...)
Affinity DataIC50: 55nMAssay Description:Inhibition of XPO1 in human HPBALL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640047(CHEMBL5556828)
Affinity DataEC50:  55nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640035(CHEMBL5563179)
Affinity DataEC50:  58nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640054(CHEMBL5562296)
Affinity DataEC50:  65nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640024(CHEMBL130007)
Affinity DataEC50:  82nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640030(CHEMBL5566432)
Affinity DataEC50:  84nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640033(CHEMBL5564519)
Affinity DataEC50:  91nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50062648(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataEC50:  106nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50619732(CHEMBL3898452)
Affinity DataIC50: 112nMAssay Description:Inhibition of XPO1 in human MOLT-16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640025(CHEMBL5566341)
Affinity DataEC50:  137nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640018(CHEMBL5555764)
Affinity DataEC50:  137nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640052(CHEMBL5561263)
Affinity DataEC50:  146nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50527779(CHEMBL4440028)
Affinity DataIC50: 151nMAssay Description:Inhibition of CRM1 in human HCT-15 cells assessed as reduction in cell viability incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50: 151nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640034(CHEMBL5560350)
Affinity DataEC50:  206nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  214nMAssay Description:Binding affinity to human XPO1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640027(CHEMBL5565311)
Affinity DataEC50:  261nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50617989(CHEMBL5401589)
Affinity DataIC50: 270nMAssay Description:Inhibition of CRM1 nuclear export in human HeLa cells assessed as CRM1 depletion measured after 6 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50617989(CHEMBL5401589)
Affinity DataIC50: 280nMAssay Description:Inhibition of CRM1-mediated nuclear export in human HeLa cells expressing mCherry-tagged NES reporter incubated for 3 hrs by confocal microscopy anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50617991(CHEMBL5437643)
Affinity DataIC50: 340nMAssay Description:Inhibition of CRM1-mediated nuclear export in human HeLa cells expressing mCherry-tagged NES reporter incubated for 3 hrs by confocal microscopy anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640049(CHEMBL5567104)
Affinity DataEC50:  358nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640048(CHEMBL5563366)
Affinity DataEC50:  404nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetExportin-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50640019(CHEMBL5567882)
Affinity DataEC50:  501nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
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