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Report error Found 8535 Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1'
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286987(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)
Affinity DataIC50: 0.100nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286987(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)
Affinity DataIC50: 0.100nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286987(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)
Affinity DataIC50: 0.100nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602226(CHEMBL5177696)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50634941(CHEMBL5556891)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50634964(CHEMBL5557389)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50588744(CHEMBL5189383)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532674(CHEMBL4557949)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532674(CHEMBL4557949)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM302362(6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...)
Affinity DataIC50: 0.200nMAssay Description:Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to FGFR1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50189870(CHEMBL3827818)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532684(CHEMBL4542061)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532684(CHEMBL4542061)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATP at Km concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50065454(CHEMBL3348846 | CHEBI:63453)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50166610(CHEMBL3800526)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50634945(CHEMBL5558932)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602224(CHEMBL5178408)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602229(CHEMBL5181688)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602225(CHEMBL5187998)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50634950(CHEMBL5505835)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50525939(Balversa | Erdafitinib | Jnj-42756493)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602223(CHEMBL5186645)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602227(CHEMBL5202576)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602235(CHEMBL5186714)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50260190(CHEMBL4100258)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50602222(CHEMBL5182360)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM434566(US10562900, Example 63)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532673(CHEMBL4447359)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286978(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 0.300nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50520607(CHEMBL4461734)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM302404(US9598416, Example 50)
Affinity DataIC50: 0.300nMAssay Description:Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50520608(CHEMBL4438578)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532662(CHEMBL4447575)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532662(CHEMBL4447575)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532680(CHEMBL4553127)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM434566(US10562900, Example 63)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50189872(CHEMBL3827492)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50520597(CHEMBL4475243)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM286978(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandPNGBDBM50532680(CHEMBL4553127)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human FGFR1 using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
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