Compile Data Set for Download or QSAR
Report error Found 1246 Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 35'
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689169(US20240254093, Example 16 | 3-((3-(6- (benzyloxy)p...)
Affinity DataKi:  0.0600nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689158(US20240254093, Example 5 | N-benzyl-3'-((2- hydrox...)
Affinity DataKi:  0.0800nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689168(US20240254093, Example 15 | 3-((5-(1H-tetrazol-5- ...)
Affinity DataKi:  0.160nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575533(CHEMBL4857772)
Affinity DataEC50:  0.310nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689165(US20240254093, Example 12 | 3'-((2-hydroxy-3,4- di...)
Affinity DataKi:  0.310nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689131(US20240254093, Example 3 | 3-((5-(1H-tetrazol-5- y...)
Affinity DataKi:  0.350nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689172(US20240254093, Example 19 | 3-((3-(1H-tetrazol-5- ...)
Affinity DataKi:  0.360nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689179(US20240254093, Example 26 | 3-((3-(6-(2-(3,5- bis(...)
Affinity DataKi:  0.360nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689178(US20240254093, Example 25 | 3-((3-(1H-indazol-5- y...)
Affinity DataKi:  0.370nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689176(US20240254093, Example 23 | 3-((3-(1H-tetrazol-5- ...)
Affinity DataKi:  0.460nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689162(US20240254093, Example 9 | 3-hydroxy-4-((3'- metho...)
Affinity DataKi:  0.460nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575533(CHEMBL4857772)
Affinity DataIC50: 0.470nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689129(US20240254093, Example 2 | 3-((3-(1H-tetrazol-5- y...)
Affinity DataKi:  0.480nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50440040(CHEMBL2425821)
Affinity DataKi:  0.589nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689167(US20240254093, Example 14 | 3-((4-chloro-3-(1H- te...)
Affinity DataKi:  0.600nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataEC50:  0.710nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575549(CHEMBL3306990)
Affinity DataIC50: 0.740nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689182(US20240254093, Example 29 | 3-hydroxy-4-((3- (pyri...)
Affinity DataKi:  0.740nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689180(US20240254093, Example 27 | 3-((3-(1H-tetrazol-5- ...)
Affinity DataKi:  0.75nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689174(US20240254093, Example 21 | 3-((3-(2-benzyl-2H- in...)
Affinity DataKi:  0.910nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50436006(CHEMBL2392171)
Affinity DataKi:  0.938nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689166(US20240254093, Example 13 | 3-((4-fluoro-3-(1H- te...)
Affinity DataKi:  0.990nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689173(US20240254093, Example 20 | 3-((3-(1H-tetrazol-5- ...)
Affinity DataKi:  1.06nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50436000(CHEMBL2392179)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575549(CHEMBL3306990)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50440042(CHEMBL2425819)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689161(US20240254093, Example 8 | 3'-((2-hydroxy-3,4- dio...)
Affinity DataKi:  1.47nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50440041(CHEMBL2425820)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689184(US20240254093, Example 31 | N-(4- carbamoylbenzyl)...)
Affinity DataKi:  1.61nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689159(US20240254093, Example 6 | N-benzyl-3'-((2- hydrox...)
Affinity DataKi:  1.82nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50440043(CHEMBL2425824)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM38549(MLS000028605 | cid_25096 | CHEMBL170358 | SMR00005...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM38549(MLS000028605 | cid_25096 | CHEMBL170358 | SMR00005...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response measured for 60 mins by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575548(CHEMBL4870213)
Affinity DataIC50: 2nMAssay Description:Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575549(CHEMBL3306990)
Affinity DataIC50: 2nMAssay Description:Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM38549(MLS000028605 | cid_25096 | CHEMBL170358 | SMR00005...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at human GPR35 by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50436003(CHEMBL2392172)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575524(CHEMBL4856506)
Affinity DataIC50: 2.5nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689171(US20240254093, Example 18 | 3-hydroxy-4-((6- pheny...)
Affinity DataKi:  2.65nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689163(US20240254093, Example 10 | 3-((3-ethyl-5-(1H- tet...)
Affinity DataKi:  2.75nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689160(US20240254093, Example 7 | 3'-((2-hydroxy-3,4- dio...)
Affinity DataKi:  2.77nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM38549(MLS000028605 | cid_25096 | CHEMBL170358 | SMR00005...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at GPR-35 (unknown origin) expressed in HT-29 cells by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575523(CHEMBL4859764)
Affinity DataIC50: 3nMAssay Description:Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50259839(CHEMBL4100677)
Affinity DataEC50:  3nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells incubated for 1 hr by DMR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50436010(CHEMBL2392141)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at human GPR35 by Ca+2 release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50575551(CHEMBL4876009)
Affinity DataIC50: 3.5nMAssay Description:Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689175(US20240254093, Example 22 | 3-hydroxy-4-((6- pheno...)
Affinity DataKi:  3.66nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM689157(US20240254093, Example 4 | ethyl 3'-((2-hydroxy- 3...)
Affinity DataKi:  3.83nMAssay Description:Overexpression of Human GPR35a Baculovirus in HEK293f cells at a cell density of 2.5��106 cells/mL and a multiplicity of infection of 2.5 over 24 h i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2024
Entry Details
US Patent

TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50614740(CHEMBL5281778)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to Nluc-fused human GPR35 expressed in CHO-K1 cells using furimazine as substrate incubated for 30 mins in presence of zaprinast fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetG-protein coupled receptor 35(Human)
Heptares Therapeutics Limited

US Patent
LigandPNGBDBM50259889(Lodoxamide)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human GPR35 by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
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