Compile Data Set for Download or QSAR
Report error Found 3406 Enz. Inhib. hit(s) with Target = 'GTPase NRas'
TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50097071(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM538632(NCGC 00371858 | US11254667, Compound I-38 | US115...)
Affinity DataIC50: 2nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
US Patent

TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM538632(NCGC 00371858 | US11254667, Compound I-38 | US115...)
Affinity DataIC50: 2nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592031(US11566007, Example A711)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61R](Human)
Revolution Medicines

US Patent
LigandPNGBDBM751132(US20250195521, Example A577)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592041(US11566007, Example A721)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592019(US11566007, Example A699)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592027(US11566007, Example A707)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592025(US11566007, Example A705)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591568(US11566007, Example A246)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM751132(US20250195521, Example A577)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591567(US11566007, Example A245)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591566(US11566007, Example A244)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591569(US11566007, Example A247)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592047(US11566007, Example A727)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61K](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591709(US11566007, Example A388)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61R](Human)
Revolution Medicines

US Patent
LigandPNGBDBM751151(US20250195521, Example A594)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591794(US11566007, Example A474 | US11566007, Example A47...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591794(US11566007, Example A474 | US11566007, Example A47...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591799(US11566007, Example A479)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM750855(US20250195521, Example A325)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM750853(US20250195521, Example A323)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591590(US11566007, Example A268)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591588(US11566007, Example A266)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM751151(US20250195521, Example A594)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591592(US11566007, Example A270)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM751049(US20250195521, Example A501)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591847(US11566007, Example A527)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591849(US11566007, Example A529)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591579(US11566007, Example A257)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591577(US11566007, Example A255)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM751133(US20250195521, Example A578)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591829(US11566007, Example A509)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591871(US11566007, Example A551)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591616(US11566007, Example A294)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591870(US11566007, Example A550)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591622(US11566007, Example A300)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591876(US11566007, Example A556)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591621(US11566007, Example A299)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591620(US11566007, Example A298)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591619(US11566007, Example A297)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591854(US11566007, Example A534 | (2S)-2-((S)-7-(4-(dimet...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591856(US11566007, Example A536 | US11566007, Example A53...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591864(US11566007, Example A544)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591863(US11566007, Example A543)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591862(US11566007, Example A542 | The synthesis of 1-(4-(...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591614(US11566007, Example A292)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591612(US11566007, Example A290)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591417(US11566007, Example A95 | Synthesis of (2S)-N-[(8S...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

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