Report error Found 344 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-6/beta-3'
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 3.00E+6nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.50E+3nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.40E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 1.40E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 4.60E+5nMAssay Description:Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataEC50: 2.44E+3nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha6beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataEC50: 170nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha6beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sci...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sci...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sci...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 930nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintill...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.09E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintill...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 2.18E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 3.06E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 3.39E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 4.07E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintill...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 4.34E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid sc...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 5.51E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz
Curated by ChEMBL
Johannes Gutenberg University Mainz
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]Ro15-1788 from human GABAA receptor alpha6beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha-6-beta-3-gamma-2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4.60nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4.60nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 5.10nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 5.10nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha-6-beta-3-gamma-2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 5.10nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
The Royal Danish School of Pharmacy
Curated by ChEMBL
The Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 5.30nMAssay Description:Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair




3D Structure (crystal)



















