Compile Data Set for Download or QSAR
Report error Found 2207 Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor'
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50342703(rac-4-(3-(2-(3-(1-(5-chloropyrimidin-2-yl)piperidi...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50232631(CHEMBL4104464)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50232627(CHEMBL4098051)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50232631(CHEMBL4104464)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50327883(CHEMBL4172551)
Affinity DataEC50:  0.427nMAssay Description:Agonist activity at mouse GPR119 assessed as increase in cAMP levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
LigandPNGBDBM50036640(CHEMBL3354778)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50343443(tert-butyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50232622(CHEMBL4060838)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50343444(tert-butyl 4-(9-(2-fluoro-4-(methylsulfonyl)phenyl...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50204219(CHEMBL3893596)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50244791((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50244791((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50232629(CHEMBL4077033)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50343445(tert-butyl 4-(3-(4-(methylsulfonyl)phenyl)isoxazol...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50122947(CHEMBL3622182)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50232621(CHEMBL4093284)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232622(CHEMBL4060838)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50342703(rac-4-(3-(2-(3-(1-(5-chloropyrimidin-2-yl)piperidi...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50232625(CHEMBL4080222)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232627(CHEMBL4098051)
Affinity DataEC50:  0.840nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50343446(tert-butyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl...)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50013912(CHEMBL3260536)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandPNGBDBM50420842(CHEMBL2086684)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from human G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50433856(CHEMBL2382410)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from human G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50342680(tert-butyl 1'-(2-cyano-6-methylpyrimidin-4-yl)-4,4...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50036636(CHEMBL3354774)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50122756(CHEMBL3622179)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50343447(tert-butyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyra...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50240387(CHEMBL4098760)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50106208(CHEMBL3598101)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human GPR119 by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50204225(CHEMBL3912040)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50122875(CHEMBL3622170)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at mouse GPR119 by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50204229(CHEMBL3982536)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50427059(CHEMBL2322837)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50244681({6-[4-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-piperid...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50204226(CHEMBL3914281)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50122933(CHEMBL3622166)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
LigandPNGBDBM50427063(CHEMBL2322841)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50232626(CHEMBL4070965)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50204231(CHEMBL3951013)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
LigandPNGBDBM50232632(CHEMBL4083676)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50427059(CHEMBL2322837)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50232624(CHEMBL4099186)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50232629(CHEMBL4077033)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50204223(CHEMBL3904015)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
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