Report error Found 618 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, kainate 1'
Affinity DataKi: 0.0810nMAssay Description:Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes by two-electrode voltage-clamp at membrane potential -60 to -80 mV electrophys...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes by two-electrode voltage-clamp at membrane potential -60 to -80 mV electrophys...More data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
Affinity DataKi: 0.663nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
Affinity DataKi: 0.740nMAssay Description:Displacement of [3H]kianic acid from recombinant GluK1 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H](2S, 4R)-4-MeGlu (SYM-2081) from GluK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.11nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.13nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.57nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human iGluR5(Q)1b expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 3.81nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataKi: 5.08nMAssay Description:Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.29nMAssay Description:Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.89nMAssay Description:Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 7.45nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Binding assays were performed as described in [J. A. O'Brien et al. Mol Pharmacol., 2003, 64, 731-740] with slight modifications, including that ...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibresMore data for this Ligand-Target Pair
Affinity DataKi: 11.6nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity towards cloned human GluR5 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibresMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
Affinity DataKi: 14.8nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; ...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKd: 18nMAssay Description:Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibresMore data for this Ligand-Target Pair







































