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Report error Found 2606 Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT6A'
TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662989(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
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TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739500(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739493(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662990(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739494(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662985(Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739495(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739496(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534094(WO2022081807, Example 201)
Affinity DataIC50: 0.810nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739497(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM663033(Synthesis of N-(6-((1H-pyrazol-1-yl)methyl)-4-(flu...)
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662984(Synthesis of 2,6-dimethoxy-N-(4-methoxy-6-(pyridin...)
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM580748(US11492346, Example 90 | US20250122182, Example 98...)
Ligand InfoPDBSimilars
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730788(US20250122182, Example 45, WO2020/254946)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739492(N-(4-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]d...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM722767(US20250059204, Compound 44 | US20250145637, Exampl...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM533971(WO2022081807, Example 78)
Affinity DataIC50: 1.41nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM533872(WO2022081807, Example 5)
Affinity DataIC50: 1.42nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM757557(6-(Dimethylamino)-N-((2-methylquinolin-8-yl)sulfon...)
Affinity DataIC50: 1.47nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/28/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739498(N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chro...)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534119(WO2022081807, Example 226)
Affinity DataIC50: 1.79nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534154(WO2022081842, Example 29 | 6-Cyclopropyl-N-(2-etho...)
Affinity DataIC50: 1.84nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534100(WO2022081807, Example 207)
Affinity DataIC50: 1.86nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM739502(N-(4-((1H-pyrazol-1-yl)methyl)-2,3-dihydrobenzofur...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM50518833(CHEMBL4528993 | US10829446, Compound 45)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730781(US20250122182, Syn. Ex. 102)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730783(US20250122182, Syn. Ex. 107)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662998(Synthesis of 2,6-dimethoxy-N-(4-(pyridin-2-yloxy)-...)
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730790(US20250122182, Syn. Ex. 14)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730792(US20250122182, Syn. Ex. 25)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM50527355(CHEMBL4456585 | US10829446, Compound 46)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534192(WO2022081842, Example 65 | N-[(2-Cyclobutoxy-5-iso...)
Affinity DataIC50: 2.09nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

LigandPNGBDBM757469(US12357603, Example 107)
Affinity DataIC50: 2.29nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/28/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534190(WO2022081842, Example 63 | N-((5-(tert-Butyl)-2-cy...)
Affinity DataIC50: 2.46nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534121(WO2022081807, Example 228)
Affinity DataIC50: 2.57nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM757546(N-((5-(tert-butyl)-2-methoxyphenyl)sulfonyl)-6-(di...)
Affinity DataIC50: 2.63nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/28/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534187(WO2022081842, Example 60 | N-[(2-(Benzyloxy)-5-(te...)
Affinity DataIC50: 2.67nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

LigandPNGBDBM757543(N-[(5-(tert-butyl)-2-cyclobutoxyphenyl)sulfonyl]-6...)
Affinity DataIC50: 2.67nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/28/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM722787(N-(4-((1H-pyrazol-1-yl)methyl)-2,3-dihydrobenzofur...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM722778(US20250059204, Compound 55 | US20250145637, Exampl...)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534188(WO2022081842, Example 61 | N-((5-(tert-butyl)-2-(c...)
Affinity DataIC50: 2.92nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM736471(4-((1H-pyrazol-1-yl)methyl)-N- ((5-(2-hydroxypropa...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534161(WO2022081842, Example 36 | 6-Cyclopropyl-N-[2-(cyc...)
Affinity DataIC50: 3.01nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534193(WO2022081842, Example 66 | N-((5-(tert-butyl)-2-me...)
Affinity DataIC50: 3.31nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534186(WO2022081842, Example 59 | N-((5-(tert-butyl)-2-cy...)
Affinity DataIC50: 3.58nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534117(WO2022081807, Example 224)
Affinity DataIC50: 3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534118(WO2022081807, Example 225 | 6-(Azetidin-1-yl)-N-[(...)
Affinity DataIC50: 3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A [507-778](Human)
The Broad Institute

WIPO
LigandPNGBDBM534107(WO2022081807, Example 214 | 6-(azetidin-1-yl)-N-[2...)
Affinity DataIC50: 3.91nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM730780(US20250122182, Syn. Ex. 101)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM736524(5-((1H-pyrazol-1-yl)methyl)-N-((2,6- dimethoxyphen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
Go to US Patent

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