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Report error Found 94 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase NSD3'
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629736(CHEMBL5424173)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human NSD3 PPWP1 domain (247 to 402 residues) expressed in Escherichia coli assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50627876(CHEMBL5416709)
Affinity DataKd:  46nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50627888(CHEMBL5413676)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.00E+5nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  7.31E+5nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629734(CHEMBL5431913)
Affinity DataKd:  9.70E+3nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50629735(CHEMBL5427539)
Affinity DataKd:  6.80E+3nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  170nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) assessed as inhibition constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.30E+5nMAssay Description:Binding affinity to human NSD3 PWWP1 domain assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  6.50E+5nMAssay Description:Binding affinity to human NSD3 PWWP1 domain assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to NSD3 PWWP1 domain (263 to 398 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  166nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50585598(CHEMBL1235831)
Affinity DataKd:  6.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataKd:  1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50585598(CHEMBL1235831)
Affinity DataKd:  2.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50637598(CHEMBL5542461)
Affinity DataKd:  4.87E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.30E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  6.50E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  445nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50627888(CHEMBL5413676)
Affinity DataKd:  1.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  170nMAssay Description:Binding affinity to NSD3 PWWP1 domain (263 to 398 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50562969(CHEMBL4758943)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50621394(CHEMBL5438548)
Affinity DataEC50:  1.43E+3nMAssay Description:Induction of NSD3 degradation in human NCI-H1703 cells incubated for 72 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50621394(CHEMBL5438548)
Affinity DataEC50:  940nMAssay Description:Induction of NSD3 degradation in human A549 cells measured after 72 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataKd:  1.60E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555100(CHEMBL4749457)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608080(CHEMBL5277519)
Affinity DataKd:  1.66E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608081(CHEMBL5270364)
Affinity DataKd:  7.31E+5nMAssay Description:Binding affinity to recombinant human NSD3 PWWP1 domain (247 to 398 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567831(US11420970, Example 32)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567955((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567959((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567828(US11420970, Example 29)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM567822(US11420970, Example 23)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50627886(CHEMBL5438312)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50594308(CHEMBL5186268)
Affinity DataIC50: 110nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Inhibition of GST-tagged NSD3-PWWP1 domain (247 to 398 residues) (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608082(CHEMBL5265919)
Affinity DataIC50: 203nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50608080(CHEMBL5277519)
Affinity DataIC50: 203nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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