Compile Data Set for Download or QSAR
Report error Found 593 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 2'
LigandPNGBDBM50459208(CHEMBL4214342)
Affinity DataIC50: 1nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459215(CHEMBL4202685)
Affinity DataIC50: 2nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459203(CHEMBL4207036)
Affinity DataIC50: 2nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of GCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  4.70nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to MAP4K2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human GCK using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50459219(CHEMBL4207100)
Affinity DataIC50: 5nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459216(CHEMBL4213673)
Affinity DataIC50: 5nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged MAP4K2 (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50459201(CHEMBL4217421)
Affinity DataIC50: 6nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  7nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged MAP4K2 (unknown origin) expressed in baculovirus infected Sf9 insect cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50459211(CHEMBL4214863)
Affinity DataIC50: 7nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459212(CHEMBL4207753)
Affinity DataIC50: 8nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459209(CHEMBL4209948)
Affinity DataIC50: 8nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50323777(N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylami...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  8.80nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of MAP4K2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50459218(CHEMBL4211976)
Affinity DataIC50: 10nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  11nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataKd:  11nMAssay Description:Binding affinity to human MAP4K2 by Ambit titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  12nMAssay Description:Binding affinity to human MAP4K2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  14nMAssay Description:Binding affinity to human MAP4K2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50459200(CHEMBL4213019)
Affinity DataIC50: 14nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459221(CHEMBL4216786)
Affinity DataIC50: 16nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459207(CHEMBL4212663)
Affinity DataIC50: 17nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50652976(CHEMBL5705830)
Affinity DataIC50: 18nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652974(CHEMBL5705844)
Affinity DataIC50: 20nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652982(CHEMBL5705829)
Affinity DataIC50: 21nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50515041(CHEMBL4125960)
Affinity DataIC50: 22nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50459198(CHEMBL4212150)
Affinity DataIC50: 24nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50378568(CHEMBL1163016)
Affinity DataIC50: 24nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50652979(CHEMBL5705831)
Affinity DataIC50: 24nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  25nMAssay Description:Binding affinity to human MAP4K2 by Ambit titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50652977(CHEMBL5705826)
Affinity DataIC50: 27nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50459202(CHEMBL4211880)
Affinity DataIC50: 27nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataIC50: 28nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM54953(3-(2-furanyl)-6-(2-methoxy-4-nitrophenyl)-[1,2,4]t...)
Affinity DataEC50:  30nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM50652980(CHEMBL5705836)
Affinity DataIC50: 30nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50652978(CHEMBL5705846)
Affinity DataIC50: 31nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM439310(US10633348, Compound (A-8))
Affinity DataIC50: 31nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  33nMAssay Description:Binding constant for MAP4K2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50459214(CHEMBL4215989)
Affinity DataIC50: 33nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459220(CHEMBL4203337)
Affinity DataIC50: 34nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50652985(CHEMBL4791091)
Affinity DataIC50: 37nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50459213(CHEMBL4212809)
Affinity DataIC50: 39nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50: 40nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50459205(CHEMBL4210482)
Affinity DataIC50: 42nMAssay Description:Inhibition of GCK (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50652975(CHEMBL5705819)
Affinity DataIC50: 44nMAssay Description:Inhibition of MAP4K2 (unknown origin) Lys1 labeling site by KiNativ Profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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